Endocrine Abstracts

Growth hormone (GH) is thought to have a dual effect (direct and indirect) on bone metabolism. We sought to explore the inter-relationships and potential determinant factors of several markers of bone turnover in GH deficient adults (GHD), as well as possible acute changes arising from GH.24 GHD subjects [14 M, 10F; age (range, 24-74 yrs)] were studied after consent and ethical approval. They were randomised into three groups (GP) of 8 subjects, each to ...

Insulin like growth factor-1 (IGF-1) has been shown to co-vary with renal function in a number of physiological and pathological conditions. However, this relationship and possible co-variants have not been specifically explored in untreated growth hormone deficient adults (GHDA). To examine this issue, we studied 24 GHDA subjects (14M, 10F) in the fasted state twice after obtaining consent and ethical approval. The Cockcroft and Gault equation was used to calculate creatinine...

WF a 52 year old female was referred to the Hammersmith Hospital in August 2001 for further investigation of her persistently elevated fasted gut hormones (GIH) [all previously assayed at the Hammersmith Hospital]. WF was initially diagnosed with irritable bowel syndrome 16 years ago. Following an exacerbation of her condition 9 years ago, fasting gut hormones were performed, which showed gross elevation of all peptides measured.The possibility of a neuroendocrine tumour was p...